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AEBSF Protease Inhibitor 1000g

AEBSF Protease Inhibitor 1000g

SKU SF011_1000
€ 4 958,68
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AEBSF Protease Inhibitor 1000g
Product Details
P-phrases: P264 Wash skin thoroughly after handling, P280 Wear protective gloves/ eye protection, P302 + P352 IF ON SKIN: Wash with plenty of water, P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing, P332 + P313 If skin irritation occurs: Get medical advice/ attention, P337 + P313 If eye irritation persists: Get medical advice/ attention.
H-phrases: H315 Causes skin irritation, H319 Causes serious eye irritation
CAS number: 30827-99-7
Chemical formulas: C8H10FNO2SClH
Molar mass g/mol: 239,69
UN number: UN3261
Packing group: II
Hazard class: 8
HS code: 29214990
Packaging: 1000 g
Brand: CF Plus Chemicals

AEBSF Protease Inhibitor effectively inhibits serine proteases irreversibly. It comes in convenient, affordable packages.

Key features include:

  • High-quality reagents in various package sizes
  • Stable at ambient temperature for at least a week
  • When stored at -20°C stable for 2 years
  • Less toxic then PMSF and DFP
  • Enhanced solubility in water
  • Greater stability in aqueous solutions.

AEBSF targets trypsin, chymotrypsin, plasmin, kallikrein, and thrombin, inhibiting enzyme activity via acylation of the active site. Safe for use in cell culture up to 0.25mM, its aqueous solutions remain stable within pH 5-6, with limited stability beyond pH 7.5.

 

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) has been used:

  • as a protease inhibitor in plasma samples to prevent acylated ghrelin (AG) degradation
  • as a snake venom serine proteinase (SVSP) inhibitor in SVSP inhibition or AEBSF assay to test the involvement of SVSPs on the fibrinogen-clotting activity
  • as a component in NP-40 lysis buffer to resuspend cell pellets for preparing cell lysates

Recommended concentrations for use are 0.1-1 mM.

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