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Geldanamycin, 10 mg

Geldanamycin, 10 mg

SKU HN71.3
€ 327,85
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Geldanamycin, 10 mg
Product Details
HS code: 29419000
Brand: Carl Roth
Geldanamycin, min. 98 %, for biochemistry, Molar mass (M) 560,64 g/mol, Storage temp. -20 °C, CAS No. [30562-34-6], Empirical formula C29H40N2O9


Geldanamycin ≥98 %, for biochemistry

Geldanamycin arrests cells in G2 phase, thus interfering with angiogenesis and oncogenesis. The specific binding of geldanamycin to heat shock protein 90 (HSP90) and its ER homologue GP96 leads to inhibition of the chaperone, results in degradation of HSP90 substrates and, subsequently, to deregulation of central cell mechanisms - cell cycle, cell proliferation, apoptosis/cell vitality.


Due to its antitumor potential it may be used as antibiotic against several eucaryotic carcinogenic cell lines. Additionally, geldanamycin is used as inhibitor of tyrosin-kinase and during analysis of several other physiological regulatory mechanisms.


Gebruiksinstructies

Working concentration: 1-10 µg/ml.
Photo sensitive! Store protected from light.



Assay (HPLC) ≥98 %
λ max. 259 nm, 307 nm
Melting point 258-262 °C
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