Competitive inhibitor of ATP binding to the catalytic domain of tyrosin kinases. Exceptional are the insulin receptor tyrosin kinase and the serin-/threonin specific proteases, which will not be inhibited by genistein. An additional, tyrosin kinase independent, effect of genistein is the inhibition of topoisomerases I and II.
Working concentration: 10-100 µM
Assay (HPLC) | ≥98 % |
Heavy metals | ≤0,001 % |
Loss on drying | ≤1,0 % |