This antibody portfolio includes a wide range of tissue- & tumor-specific primary antibodies for basic research, product development and analysis of a variety of biological questions. The monoclonal antibodies are perfectly applicable for all cell or tissue biology studies and for the analysis of predictive markers in research.
SY 38 represents an excellent marker for several neuroendocrine, neuronal and adrenal tumors. Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas.
Neuroendocrine tumors of epithelial origin: Pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids, medullary carcinoma of thyroid.
Polypeptide reacting: 38 kDa transmembrane glycoprotein of presynaptic vesicles.
Tested cultured cell lines: rat PC-12 cell line.
Host: mouse
Antibody type: monoclonal
Isotype: IgG1
Clone: SY38
Immunogen: synaptophysin from presynaptic vesicles, prepared from bovine brain
UniprotID: P20488 (bovine), P08247 (human), Q62277 (mouse), P07825 (rat)
Synonym: synaptophysin, major synaptic vesicle protein p38, SYP
Conjugate: unconjugated
Purification: affinity chromatography
Intended use: research use only
Application: ICC/IF, IHC, WB
Reactivity: bovine, human, mouse, rat
Immunocytochemistry (ICC): assay dependent
Immunohistochemistry (IHC) - frozen: 1:50-1:200 (0.25-1 μg/ml, no protease treatment)
Immunohistochemistry (IHC) - paraffin: 1:50-1:200 (0.25-1 μg/ml, microwave treatment recommended, no protease treatment)
Western Blot (WB): 1:500-1:1,000 (0.05-0.1 μg/ml)