anti-Synaptopodin/SYNPO mouse monoclonal, G1D4, 1 ml
SKU 1NP2.2
€ 424,47
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anti-Synaptopodin/SYNPO mouse monoclonal, G1D4, 1 ml
Product Details
HS code: 30021500
Brand: PROGEN
anti-Synaptopodin/SYNPO, mouse monoclonal, G1D4, 50 µg/ml, affinity purified (made by PROGEN), Density (D) ~1 g/cm³, Boiling point (bp) ~100 °C, Storage temp. +4 °C
This antibody portfolio includes a wide range of tissue- & tumor-specific primary antibodies for basic research, product development and analysis of a variety of biological questions. The monoclonal antibodies are perfectly applicable for all cell or tissue biology studies and for the analysis of predictive markers in research.
- High epitope affinity
- Highly specific detection of the target protein
- Unconjugated
- Suitable for e.g. western blot, immunoprecipitation, ELISA & immunofluorescence
anti-Synaptopodin/SYNPO mouse monoclonal, G1D4 50 μg/ml, monoclonal, affinity purified
The antibody recognizes differentiated podocytes (glomerular visceral epithelial cells) in vivo and in vitro (weaker additional reaction with arterial endothelial cells), co-localization with alpha-actinin. Does not react with parietal cells. Reacts with a subset of exclusively telencephalic synapses. Differentiation-dependent expression during postnatal maturation of rat brain. Differentiation-dependent expression in cultured hippocampal neurons.
The antibody reacts specifically with synaptopodin, a prolin-rich actin-binding protein with 2 binding sites for actin. Synaptopodin represents a new class of actin-binding proteins which has first been localized in podocytes and a subset of telencephalic postsynaptic densities.
In human tissue synaptopodin has a molecular weight of 73.7 kDa and pI of 9.38 (calculated from sequence data); in mouse the corresponding data are 74 kDa, pI 9.27. In SDS-PAGE the antigen appears as 100 kDa polypeptide in brain and 110 kDa polypeptide in kidney (the difference might be attributed to posttranslational modifications). In Western blot analysis the antibody also reacts with a 44 kDa degradation fragment of synaptopodin.
Host: mouse
Antibody type: monoclonal
Isotype: IgG1
Clone: G1D4
Immunogen: isolated rat kidney glomeruli
UniprotID: A4IFK4 (bovine), A0A286XK19 (guinea pig), Q8N3V7 (human), Q91YE8 (mouse), D4A702 (rat)
Synonym: synaptopodin, SYNPO, KIAA1029
Conjugate: unconjugated
Purification: affinity chromatography
Intended use: research use only
Application: ICC/IF, IHC, WB
Reactivity: human, mouse, rat
No reactivity: chicken, frog, rabbit
Toepassing
Immunocytochemistry (ICC): assay dependent
Immunohistochemistry (IHC) - frozen: 1:50-1:200 (0.25-1 μg/ml)
Immunohistochemistry (IHC) - paraffin: 1:50-1:200 (0.25-1 μg/ml, microwave treatment recommended)
Western Blot (WB): assay dependent
Rat kidney (courtesy of J. Heß, University Hospital Heidelberg)
Rat kidney (courtesy of J. Heß, University Hospital Heidelberg)
Geen medisch hulpmiddel / Geen ivD-product
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